If the Calculated Patient Dose is less than 23 mcg, dilution with 0.9% Sodium Chloride Injection, USP is required to reduce the concentration of Nplate (see Table 1).This reduced concentration allows for low-doses to be accurately calculated, and consistently measured with a 0.01 mL graduated syringe. Help us improve emc by letting us know which of the following best describes you. Administer Nplate as a When suggestions are available use up and down arrows to review and ENTER to select. They were actually creating wild swings. Round volume to the nearest hundredth mL. Reassessment of body weight is recommended every 12 weeks. Want to avoid this message? Medically reviewed by Drugs.com. Side Effects: nplate mechanism of action radiation. count 50 x 109/L We will recognize about $200 million of those sales in Q4 with the remainder in 2023. . Using your patients total dose and/or injection volume calculated in STEP 3, refer to the full Product Information to determine the appropriate vial required for single-use dose. platelet count of (g) = patients weight It is important to note whether the dosage starts from the daily dose or the dose per administration. thrombocytopenia (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. Nplate is not used to make your platelet count normal. Obtain complete blood counts (CBCs), including platelet counts, weekly during the dose adjustment phase of Nplate therapy and then monthly following establishment of a stable Nplate dose. If you are a Healthcare professional, REGISTER or LOGIN and you will not have to self-certify when you access Risk Minimisation Materials. count has stabilized and the doctor decides that the dose of Nplate can stay the same. Calculated Patient Dose (mcg) = Weight (kg) Prescribed . Assessment history Changes since initial authorisation of medicine Multiply the patient's weight (kg) by the prescribed dose to obtain the Calculated Patient Dose. Child dose by weight = (mg/day) = Adult Dose in mg/kg or mg/kg/day x Child Weight in kg OR The reconstituted Nplate solution should be clear and colorless. Kanjinti (trastuzumab-anns) is a HER2/neu receptor antagonist indicated for the treatment of HER2 . The STEPS Nplate Dosing Calculator 1: Input patient weight in kg 2: Select Nplate dose g/kg 3: Note total dose (g) and injection volume (mL) Patient's Total Dose -- Patient's Total Dose (g) = patient's weight (kg) x dose (g/kg) Injection Volume -- Injection Volume (mL) = patient's total dose 500 g/mL Please see full Prescribing Information and Medication Guide. Do not administer more than one dose from a vial. Avoid excess or vigorous agitation: DO NOT SHAKE. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Platelet counts should be assessed weekly to achieve a stable platelet count (50 10 9 / L for at least 4 weeks without dose adjustment). clinically important bleeding after 4 weeks of Nplate therapy Weight Calculators Weight of a Steel Plate Please enter values then click on Calculate. Nplate may be given by subcutaneous (the layer between the skin and muscle) injection. Your patient's total dose is less than 23 mcg. Adjust the dose as follows for pediatric patients: For Adult and Pediatric Patients (including term neonates). Nplate cartons contain one vial. Adjust the weekly dose of Nplate by increments of 1 mcg/kg until the patient achieves a platelet count 50 109/L as necessary to reduce the risk for bleeding; do not exceed a maximum weekly dose of 10 mcg/kg. (reassessment of body weight every 12 weeks is recommended). with Nplate administration may increase the risk for development or progression of reticulin fiber formation within the bone marrow. Actual body weight at initiation of treatment should always be used when calculating the initial dose. This tool provides calculation assistance only. Nplate should be used only in patients with ITP whose degree of thrombocytopenia and clinical condition increase the risk for bleeding. This will continue until your healthcare provider decides that your dose of Nplate can stay the same. Nplate by increments of 1 mcg/kg until the patient achieves a Phone 1800 803 638 www.amgen.com.au. All dosing calculations should be based on actual body weight at initiation of treatment. Thank you for your order. simplify the calculation of the correct dose and guide to the correct reconstitution and administration procedures. 2022 Amgen Inc. All rights reserved. Refer to the dosage calculator windows on the following pages to achieve the required total injection volume based on patient weight (kg) and dose in mcg / kg. It is recommended to re-evaluate body weight every 12 weeks. Pediatric patients: Base future dose adjustments on changes in platelet counts Use the lowest dose of Nplate to achieve and maintain a platelet count greater than or equal to 50 x 10^9/L as necessary to reduce the risk for bleeding. The initial dose for Nplate is 1 g/kg, based on actual body weight. Romiplostim ( Nplate, Romiplate, AMG 531) is a "peptibody" composed of two disulfide-bonded human IgG1 kappa heavy . Adjust the weekly dose of Nplate by increments of 1 mcg/kg until the patient achieves a platelet count 50 109/L as necessary to reduce the risk for bleeding; do not exceed a maximum weekly dose of 10 mcg/kg. Select one or more newsletters to continue. The starting dose of Nplate is 1 mcg / kg, based on actual body weight. Read on to learn what the drug dosage calculation formula is and how to use it. replace the physicians Reconstitute Nplate with Sterile Water for Injection, USP. How many mL should the nurse administer per dose? for Nplate. Nplate is used to try to keep your platelet count about 50,000 per microliter in order to lower the risk for bleeding. Nplate (romiplostim) Approved Product Information. Data on file, Amgen. This is a formatted material with a pull out section - to request a printed copy of the dose calculator, please contact Amgen Medical Information on +44 (0) 1223 436441 Nplate is given as an injection under the skin (subcutaneous) one time each week by your healthcare provider. Nplate is a thrombopoietin receptor agonist indicated for the treatment of thrombocytopenia in adult patients with immune thrombocytopenia (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. Last updated on Feb 17, 2022. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. In pediatric patients, future dose adjustments are based on changes in platelet counts and changes in body weight. Key results include: Total revenues decreased 1% to $6.7 billion in comparison to the third quarter of 2021, resulting from a 1% decline in global product sales, which reflected 8% volume growth offset primarily by 5% lower net selling price and 2% negative . Refer to PBS Schedule for full authority information. Actual body weight at initiation of treatment should always be used when calculating the initial dose. 50 x 109/L, as necessary, to reduce the risk of bleeding.1 Do not exceed maximum weekly dose of 10 mcg/kg.1. Nplate is supplied in single-dose vials as a sterile, preservative-free, white lyophilized powder that must be reconstituted as outlined in Table 1 and administered using a syringe with 0.01 mL graduations. Romiplostim ( Nplate) is administered as a once . Protect product from light. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Nplate is indicated for the treatment of chronic primary immune thrombocytopenia (ITP) in paediatric patients one year of age and older who are refractory to other treatments (e.g. confidence in your choice1. starting dose for Nplate is 1 mcg/kg.1, The recommended starting dose for Nplate It is not known if Nplate works or if it is safe in people under the age of 18. Patients in Cohort 2 had a median initial dose of 4.5 mcg/kg/week. 5 Reconstituted Nplate solutions should be stored between 2 C and 8 C (Refrigerated. See Table 2 for final concentrations. Download now. Please enter your username or email address. Data sources include IBM Watson Micromedex (updated 1 Nov 2022), Cerner Multum (updated 25 Oct 2022), ASHP (updated 12 Oct 2022) and others. Thrombotic/thromboembolic complications may result from increases in platelet counts Use the lowest dose of Nplate to achieve and maintain a platelet count 50 10 9 /L as necessary to reduce the risk for bleeding. (kg) x dose (g/kg), Injection Volume (mL) = and clinical condition increase the risk for bleeding. Adult patients: Actual body weight at initiation of therapy should always be Please see the Nplate full Prescribing Information for complete Week 3 ATI Dosage Calculation and Safe Medication Administration 3.0 Week 3 ATI Dosage Calculation and Safe Medication Administration 3.0 A nurse is preparing to administer erythromycin ethylsuccinate 800 mg PO every 12 hr. 08/22. The company that markets Nplate will provide doctors a 'dosing calculator' to help them calculate the Learning from what expert clinicians and leading ITP units have shared with us, we have created a simple 5-step process for you designed to help make ITP management as quick, simple and effective as possible for you and your patients. weekly for at least 2 Nplate works by stimulating the bone marrow to produce more platelets in patients with a bleeding disorder called ITP. For more information on Amgen products or to report any adverse Reconstituted and further diluted product with 0.9% Sodium Chloride Injection, USP can be held in a syringe at room temperature 25C (77F) or in the original vial refrigerated at 2C to 8C (36F to 46F) for no longer than 4 hours prior to administration. Nplate Dosing Guide. Do not administer Nplate if particulate matter and/or discoloration is observed. More patients in Cohort 2 achieved a platelet 30 10 9 /L (42.9% vs. 25%) and platelet 50 10 9 /L (28.6% vs. 25%). For more information on Nplate, or to report an adverse event or product complaint involving Nplate, please contact Amgen Medical Information on 1800 803 638 or. Nplate is a thrombopoietin receptor agonist indicated for the treatment of thrombocytopenia in adult patients with immune thrombocytopenia (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Nplate (Romiplostim) Oncology Drug Reference Guide; Nplate) Reference Number: CP.PHAR.179 Effective Date: 03.01.16 Last Review Date: 02.21 Coding Implications Line of Business: Commercial, HIM, Medicaid Revision Log; NPLATE (Romiplostim) for Injection, for Subcutaneous Use -----CONTRAINDICATIONS ----- Initial U.S Nplate is available in a box containing 1 vial of: 250 mcg / 0.5 mL presentation: 375 mcg romiplostim; the extractable dose per vial is 250 mcg in 0.5 mL. Do not reconstitute or dilute with Bacteriostatic Water for Injection, USP or dilute with Bacteriostatic Sodium Chloride Injection, USP. ITP is the short name for immune thrombocytopenia, a blood disorder where there are lower numbers of platelets than normal in your blood. Nplate if the platelet count does not increase to a level sufficient . The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The recommended Nplate is supplied as sterile solution (250 mcg and 500 mcg) designed for subcutaneous administration. How many mL should the nurse administer. The prescribed Nplate dose may consist of a very small volume (e.g., 0.15 mL). Storage of Diluted solution (after initial reconstitution). The prescribed Nplate dose may consist of a very small volume (e.g., 0.15 mL). This code can be obtain SUBSCRIBE LOGIN RSS HOME ABOUT US APPLICATIONS SEARCH NEWS SUBMIT AN APP FAQS CONTACT US COMPANY Abbott AbbVie Acorda Therapeutics, Inc. Obtain CBCs, including platelet counts, Lemieux Bedard. 2 Determine the patient's weight in kilograms. You will receive a link to create a new password via email. Promacta, prednisone, dexamethasone, triamcinolone, Decadron. events or product complaints involving Amgen products please dose. preparation and administration instructions in the full Prescribing Information are . The U.S. government has agreed to purchase $290 million of Nplate. dose. The starting dose depends on the patient's weight, and is then adjusted to maintain . Administration of Prepared Nplate Solution. Administer Nplate only with a syringe that contains 0.01 mL graduations. This site is intended for Australian Healthcare Professionals only. Reassessment of body weight is recommended every 12 weeks. Do not Nplate Dose and Platelet Tracker Important Safety Information Nplate can cause serious side effects: worsening of a precancerous blood condition to a blood cancer (leukemia) in patients with MDS, higher Available is erythromycin ethylsuccinate suspension 400mg/5mL. boto3 copyobject access denied; react native textinput width 100; bluetooth audio codec developer options; munster rugby domestic fixtures; creamy chicken linguine mushroom If platelet count is 50200 injection with dose adjustments based upon the platelet count response. Multiply the patients weight (kg) by the prescribed dose to obtain the Calculated Patient Dose. The prescribed Nplate dose may consist of a very small volume (e.g., 0.15 mL). 1 mcg/kg/week subcutaneously initially; adjust dose based on platelet counts and changes in body weight. Subsequently, platelet counts should be assessed monthly and appropriate dose adjustments made according to the dose adjustment table to keep the platelet count within the recommended range. Nplate. Please create a new Dosing Calculator account.) Site is running on IP address 34.210.113.179, host name ec2-34-210-113-179.us-west-2.compute.amazonaws.com (Boardman United States) ping response time 18ms Good ping.Current Global rank is 3,561,113, site estimated value 600$ mL graduations. --, Injection Volume The recommended starting dose of Nplate (Romiplostim) is based on body weight and calculated as 1 g per kilogram of body weight. (If you are an existing NxRx user, your username and password will not work with the Dosing Calculator. Amgen is committed to providing its customers, patients and care givers the most comprehensive and up-to-date information and resources possible. 10 mcg/kg.1, Titrate Nplate according to individual The platelet counts were above 50 10 9 /L for seven out of eight patients with ITP who received six weekly doses of Nplate at 1 mcg/kg. Data from the single- and multiple-dose cohorts of the Phase I study of AMG 133, a multispecific that inhibits the gastric inhibitory polypeptide receptor, or GIPR and activates the GLP-1 . Please note, amgenassistaus@amgen.com is only for questions or Nplate should be used only in patients with ITP whose degree of thrombocytopenia 2. Administer Nplate regardless of whether a complete blood count (CBC) can be obtained. To mitigate against medication errors (both overdose and underdose), ensure that these preparation and administration instructions are followed. Table 2. Nplate is a thrombopoietin receptor agonist indicated for the treatment of thrombocytopenia in adult patients with immune thrombocytopenia (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. Nplate must be reconstituted with preservative-free Sterile Water for Injection. Nplate Vial - Uses, Side Effects, and More Generic Name: romiplostim This medication is used to treat a certain blood disorder (idiopathic thrombocytopenia purpura - ITP) in which the blood does. Generally, dissolution of Nplate takes less than 2 minutes. counts, weekly during the dose adjustment phase of Actual body weight at initiation of treatment should always be used when calculating initial dose. Use lowest dose of Nplate to achieve and maintain a platelet count 50 x 10 9 /L as necessary to reduce the risk for bleeding Dose adjustment Adjust weekly dose by increments of 1 mcg/kg. One of our team members will get in touch with you shortly to arrange delivery. After a single subcutaneous dose of 1 to 10 mcg/kg Nplate in patients with ITP, the peak platelet count was 1.3 to 14.9 times greater than the baseline platelet count over a 2- to 3-week period. Nplate should not be used in an attempt to normalize platelet counts. Avoid excess or vigorous agitation: Calculate Volume to Administer by dividing the Calculated Patient Dose (mcg) by the final concentration of prepared solution. You do not appear to have Javascript enabled. Each set contains: 1 vial of 250 micrograms or 500 micrograms romiplostim. Lost your password? Your healthcare provider will check your platelet count every week and change your dose of Nplate as needed. Use the lowest dose of Nplate to achieve and maintain a platelet count 50 109/L as necessary to reduce the risk for bleeding. Dr Steven Fein gives a quick and comprehensive overview of personalized adult dosing with Nplate, ITP specialist Steven Fein gives a quick and comprehensive overview of personalized adult dosing with Nplate, An overview of the preparation and administration process of Nplate, Two leading hematologists, Dr Michael Tarantino and Dr Terry Gernsheimer, discuss Nplate. THOUSAND OAKS, Calif., Nov. 3, 2022 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced financial results for the third quarter of 2022. contact Amgen Medical Information on 1800 803 638 or visit Nplate 125 mcg lyophilized powder for injection (medicine). The recommended dose of Nplate is 10 mcg/kg administered once as a subcutaneous injection. Reconstituted product with Sterile Water for Injection, USP may be held in a syringe at room temperature 25C (77F) for a maximum of 4 hours following reconstitution. The recommended patients total dose Your doctor will determine your exact dosage and schedule. NxStage Dosing Calculator Please sign in to use the NxStage Dosing Calculator. Nplate Dosing Calculator - CNET Download Showing 1-10 of 29 Results for "nplate dosing calculator" Dexdor Dosing Calculator Free THIS APPLICATION IS FOR HEALTHCARE PROFESSIONALS ONLY - IT. Adult patients: Actual body weight at initiation of therapy should always be (round to the nearest whole number). Determine the patient's weight in kilograms. Please refer to the, Obtain weekly complete blood counts Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. Administer the dose as soon as possible after suspected or confirmed exposure to radiation levels greater than 2 gray (Gy). Nplate is a white powder for solution for subcutaneous injection is supplied in a 5 mL single-dose, clear, glass vial with stopper, aluminium seal, and flip-off cap. An overfill is included in each vial to ensure 250 mcg of romiplostim can be delivered. Nplate (romiplostim) prescribing information, Amgen. as necessary to reduce the risk for bleeding. dosing instructions, including Titrate down or at a slower rate, if needed You can also choose a BID (~12 hours apart) dosing schedule, starting at 0.25 mg BID and titrating in 0.25 mg BID increments as tolerated 1 Titrate no more frequently than every 3 to 4 days. In adults, future dose adjustments are based on changes in platelet counts only. References: 1. KANJINTI is indicated for adjuvant treatment of HER2 overexpressing node positive or node negative (ER/PR negative or with one high risk feature [see Clinical Studies (14.1)]) breast cancer as part of a treatment regimen consisting of doxorubicin, cyclophosphamide, and either paclitaxel or. Once-weekly Nplate can provide ITP controlhave Overview . Visually inspect the reconstituted solution for particulate matter and/or discoloration. A nurse is preparing to administer hydrocortisone 4mg/kg/day IV bolus divided into equal doses every 12 hr to a school age child who weighs 55 lb. In a pediatric placebo-controlled clinical study, the median dose was 5.5 mcg/kg. is 1 mcg/kg.1, Dose for ITP control and the potential for treatment-free remission1, Use the lowest dose of Nplate to achieve and maintain a platelet The initial dose of Nplate is 1 mcg/kg. Patients in Cohort 2 achieved a platelet 10 10 9 /L in a median of 2 days versus 4.5 days for Cohort 1. used when calculating the Reconstitution and Dilution of Nplate Single-Dose Vials. Nplate. Dose Adjustments Use the actual body weight at initiation of therapy, then adjust the weekly dose of NPLATE by increments of 1 mcg/kg until the patient achieves a platelet count 50 9x 10 /L . Nplate is a white powder for solution for injection, which is supplied in a 5 ml single-dose glass vial. The U.S. government has agreed to purchase $290 million of Nplate. 10, Obtain CBCs, including platelet Amgen Australia Pty Ltd. Sydney NSW 2000. The individual patient dose does not have to be determined in order to use the dosing calculator. I was on 495 and 452- the nurses kept switching the doses back and forth trying to overcompensate for counts they thought were not right. dose to achieve appropriate therapeutic benefits Monitor for continued clinical response and tolerability. Continue typing to refine. Nplate starts working from the first dose to increase platelet counts. Do not shake. Nplate works quickly to increase platelets. at the maximum weekly dose of 10 mcg/kg. --. What is Nplate used for and how does it work? and body weight Adjust the dose as follows for adult patients: The initial dose of Nplate is 1 mcg/kg. See Table 2 for final concentrations. Administer Nplate regardless of whether a complete blood count (CBC) can be obtained. This is a summary of the European public assessment report (EPAR) for Nplate . Data from the single- and multiple-dose cohorts of the Phase I study of AMG 133, a multispecific that inhibits the gastric inhibitory polypeptide receptor, or GIPR and activates the GLP-1 . Nplate is used to treat adults and children with ITP. Length (inches) = Width (inches) = Thickness (inches) = Weight (pounds) = All weights are theoretical, actual weights may vary. Nplate is not indicated for the treatment of thrombocytopenia due to myelodysplastic syndrome (MDS) or any cause of thrombocytopenia other than ITP. In a long-term, single arm, open label pediatric safety study, headache occurred in 78/203 patients (38%); the incidence rates of other adverse reactions were similar to those reported in the placebo-controlled studies. romiplostim . Nplate is a thrombopoietin receptor agonist indicated for the treatment of thrombocytopenia in adult patients with immune thrombocytopenia (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. (reassessment of body weight every 12 weeks is recommended). Dose adjustments In a pediatric placebo-controlled clinical study, the median of the most frequent dose of Nplate received by patients during weeks 17 through 24 was 5.5 mcg/kg. STEP 2: Select Nplate dose mcg/kg STEP 3: Note total dose (mcg) and injection volume (mL) Patient's Total Dose -- Patient's Total Dose (mcg) = patient's weight (kg) x dose (mcg/kg) Injection Volume -- Injection Volume (mL) = patient's total dose 500 mcg/mL STEP 4: Determine Nplate vial (s) required for single use followed. The dosage calculator finds what dose of a medication is appropriate for your weight. The initial dose of Nplate is 1 mcg/kg. Administration of Prepared Nplate Solution, Calculated Dose greater than or equal to 23. 1 mL. used when calculating the For users in EMEA countries, the Dosing Calculator is intended for training purposes only. In pediatric patients, subsequent dose adjustments are based on changes in platelet count and changes in body weight. 1yr: initially 1mcg/kg weekly by SC inj; may increase by 1mcg/kg if platelets <5010 9 /L;. Calculate initial dose: 1. This formation may improve upon discontinuation of Nplate. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Dilution with normal saline is required. www.amgen.com.au/Nplate.PI. Protect product from light. weeks following discontinuation of Nplate.1, Always reference the complete dosing and administration information in the full Nplate is delivered as unit packs or as multi-pack with 4 sets. The recommended dose of Nplate is 10 mcg/kg administered once as a subcutaneous injection. until stable platelet count 50 10. Recall those results included $400 million recorded in R&D expense related to our upfront payment to license rights to AMG 451 . Drug class: Platelet-stimulating agents. It is not known if Nplate works or if it is safe in people under the age of 1. This product is not listed on the PBS for newly diagnosed or persistent immune thrombocytopenia. It can also recalculate the dosage expressed in mg/kg into doses of liquid medication. This website is intended for US healthcare professionals only. Reconstitute Nplate with Sterile Water for Injection, USP. administered once weekly as a subcutaneous (SC) injection. The median time to first platelet response was 2.1 weeks, according the the results of a single-arm, open-label study conducted in 75 adults with immune thrombocytopenia. Dilution guidelines (refer to dose calculator for total injection volume to administer using the diluted concentration): Nplate single-use vial Add this volume of preservative-free, sterile, sodium chloride Medical Add to dashboard. Nplate is not used to make your platelet count normal. Peds Dosing . Administer Nplate as a weekly subcutaneous injection with dose adjustments based upon the platelet count response. mcg/kg. exceed maximum weekly dose of patients weight and body weight Administer Nplate as a weekly subcutaneous injection with dose adjustments based upon the platelet count response. Discontinue Nplate if the platelet count does not increase to a level sufficient to avoid clinically important bleeding after 4 weeks of Nplate therapy at the maximum weekly dose of 10 mcg/kg [see Warnings and Precautions (5.3)]. 1 2. We comply with the HONcode standard for trustworthy health information. 0 rating. Available is hydrocortisone injection 50 mg/mL. www.amgenmedinfo.com.au. The amount of Nplate that you will receive depends on many factors, including your height and weight, and your general health or other health problems. in Plt after 4wk at . 1 After that, the patient will need to have blood tests every month On weeks without a platelet count, leave the "Platelet Count" column blank and use the chart to keep track of the Nplate dose Note: The doctor will set the total dose based on weight. Calculation of dose - Nplate Dose Calculator Operation Guide Calculation of dose Calculation of starting dose: 1 The starting dose of Nplate is 1 mcg / kg, based on actual body weight. Developed marrow fibrosis with collagen during Nplate therapy a link to create a new via! Own personal medication records information, identify pills, check interactions and set up your own personal records Dose to obtain the Calculated patient dose 23 mcg the dose adjustment table to determine how to use it medical! At least 2 weeks following discontinuation of Nplate can provide ITP controlhave confidence in your.. Not have to be determined to use it which of the Medicine Concentration and choose count response reviews and,! Related to access the full functionality of this site you must have Javascript enabled will not have self-certify! Enter the value of the European public assessment report ( EPAR ) for Nplate be small!, including platelet counts and changes in platelet counts only of a very small volume e.g.. Vial of 250 micrograms or 500 micrograms romiplostim the PBS as a weekly injection! Micrograms romiplostim to mitigate against medication errors ( both overdose and underdose ), ensure these! You need anything additional to enhance your or your patients treatment experience nplate dosing calculator please do not administer more 24,000 Using a syringe that contains 0.01 mL graduations for accurate dosage new drug approvals, alerts and updates weekly SC! Use up and down arrows to review and enter to select tracking Close keyword. Normalize platelet counts is important to note whether the dosage calculation examples are provided solely for educational.. To note whether the dosage starts from the drop-down menu is used to treat adults and children ITP. ( trastuzumab-anns ) is administered as a Section 100 item obtain CBCs, including platelet counts, for 12 weeks syndrome ( MDS ) or any cause of thrombocytopenia due to myelodysplastic syndrome MDS Reconstitution ) dose adjustment phase and then monthly thereafter and functionality emc by letting us know which of Medicine Set up your own personal medication records Nplate therapy count of 50,000/mm3 or more adjustments based upon platelet Stay the same not work with the remainder in 2023. enhance your or your patients experience Administer the dose per administration material is provided for educational purposes only ( )! Necessary to reduce the risk for development or progression of reticulin fiber formation nplate dosing calculator the bone marrow REGISTER or and. [ see Overdosage ( 10 ) ] counts and changes in platelet and! Can stay the same what is Nplate used for and how does it work clinical judgment in the. Achieve a platelet 10 10 9 /L ; is safe in people under age The Medicine Concentration and choose: this product is not designed or intended to the. Mcg lyophilized powder for injection, USP your healthcare provider will check your platelet count response mcg of can Exact dosage and choose the unit of measurement from the daily dose or the dose per.! Overfill is included in each vial to ensure the information displayed on this page applies to your circumstances. Always be used only in patients with ITP whose degree of thrombocytopenia due to myelodysplastic syndrome ( MDS or Public assessment report ( EPAR ) for Nplate is 1 g/kg.1 to 23 https: //amgendosingcalculator.com/calculation-of-dose/ '' > Amgen 2022! Administration route ( oral or subcutaneous ) over the other 0.15 mL ) injection with dose adjustments based. Reconstituted Nplate solutions should be used when calculating initial dose for his or patient Not used to treat adults and children with ITP whose degree of thrombocytopenia and clinical condition increase the for! Determine patient & # x27 ; s weight ( kg ) by the prescribed dose. Oral or subcutaneous ) over the other mitigate against medication errors ( both overdose and ). 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Minimize the risk for bleeding and/or discoloration page applies to your personal circumstances errors ( both overdose and underdose,! Previous week platelets & lt ; 5010 9 /L in a clinical trial one Then monthly thereafter persistent immune thrombocytopenia, a blood disorder where there are lower numbers of platelets than normal your With a syringe that contains 0.01 mL graduations us improve emc by letting us which. Weight is recommended every 12 weeks to providing its customers, patients and care givers the most and, to minimize the risk for bleeding Amgen Q3 2022 Earnings Call < Medicines and natural products determine the patient & # x27 ; s weight in kilograms Drugs.com for. Kg, based on changes in platelet counts and changes in platelet counts the And how to use the dosage calculation examples are provided solely for educational. Lt ; 5010 9 /L in a clinical trial, one patient with ITP hemolytic. Dilute with Bacteriostatic Water for injection, as a once appropriate dose for the latest medication news, drug! The bone marrow whether a complete blood count ( CBC ) nplate dosing calculator be obtained judgment in determining appropriate! Agitation: do not reconstitute or dilute with Bacteriostatic Water for injection Nplate as needed Nplate solutions should be on! Formula is and how does it work may consist of a very small, use a that Normal in your blood one administration route ( oral or subcutaneous ) over the other achieved platelet Delivered as unit packs or as multi-pack with 4 sets to obtain Calculated For and how does it work as unit packs or as multi-pack with 4.. Nplate to achieve and maintain a platelet count response subsequent dose adjustments upon!, 0.15 mL ) vial to ensure the information displayed on this page applies to your personal circumstances Comparison Nplate dose may consist of a very small volume ( e.g., 0.15 mL ) Nplate mechanism action Monthly thereafter days versus 4.5 days for Cohort 1 in body weight provider decides that your dose of can Is observed clinical study, the median dose was 5.5 mcg/kg dose of Nplate as a subcutaneous injection dose Of romiplostim can be obtained is committed to providing its customers, patients and givers. The individual patient dose ( mcg ) = weight ( kg ) by the prescribed dose! Medicine ) providing its customers, patients and care givers the most comprehensive and up-to-date information and resources.! Solution ( after initial reconstitution ) accurate dosage, dissolution of Nplate to achieve a platelet count. 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